Defragging the whole drive, currently 0% fragmented, and says the drive is in Good Health, and is status OK.
Disabling Windows Search, SysMain (Superfetch) all those services that pop up in relative Google searches, to no avail. My 7200 rpm HDD has this fluctuating issue where whenever I use a program for an extended period of time (usually 3ds Max/Maya, alike program of the stature) or play any modern game for extended time (mainly FFXII The Zodiac Age), on exit any programs I open cause the disk to fire up to 100% disk usage for around 30 seconds or longer, it's ridiculous. I've been having this issue lately, and I am baffled on why it occurs.